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Gonal F 450IU Vial Follitropin Alpha, Pack of 1
Each Gonal F 450IU Vial is a multidose vial containing 44 micrograms of follitropin alfa (equivalent to 600 IU) in order to deliver 33 micrograms (equivalent to 450 IU) in 0.75 mL. Each mL of the reconstituted solution contains 600 IU.
What Gonal F 450IU Vial is
Gonal F 450IU Vial contains a medicine called “follitropin alfa”. Follitropin alfa is a type of “Follicle Stimulating Hormone” (FSH) which belongs to the family of hormones called “gonadotropins”. Gonadotropins are involved in reproduction and fertility.
What Gonal F 450IU Vial is used for
In adult women, GONAL f 450iu is used:
• to help release an egg from the ovary (ovulation) in women that cannot ovulate and that did not respond to treatment with a medicine called “clomiphene citrate”.
• together with another medicine called “lutropin alfa” (“Luteinising Hormone” or LH) to help release egg from the ovary (ovulation) in women that are not ovulating because their body is producing very little gonadotropins (FSH and LH).
• to help develop several follicles (each containing an egg) in women undergoing assisted reproductive technology procedures (procedures that may help you to become pregnant) such as “in vitro fertilisation”, “gamete intra-fallopian transfer” or “zygote intra-fallopian transfer”.
In adult men, GONAL f is used:
• together with another medicine called “human Chorionic Gonadotropin” (hCG) to help produce sperm in men that are infertile due to a low level of certain hormones.
What is Infertility
Infertility is when a couple cannot get pregnant (conceive) despite having regular unprotected sex.
Around 1 in 7 couples may have difficulty conceiving.
About 84% of couples will conceive naturally within a year if they have regular unprotected sex (every 2 or 3 days).
For couples who have been trying to conceive for more than 3 years without success, the likelihood of getting pregnant naturally within the next year is 1 in 4, or less.
Some people get pregnant quickly, but for others it can take longer. It’s a good idea to see a GP if you have not conceived after a year of trying.
Women aged 36 and over, and anyone who’s already aware they may have fertility problems, should see their GP sooner.
They can check for common causes of fertility problems and suggest treatments that could help.
Infertility is usually only diagnosed when a couple have not managed to conceive after a year of trying.
There are 2 types of infertility:
- primary infertility – where someone who’s never conceived a child in the past has difficulty conceiving
- secondary infertility – where someone has had 1 or more pregnancies in the past, but is having difficulty conceiving again
Fertility treatments include:
- medical treatment for lack of regular ovulation
- surgical procedures such as treatment for endometriosis, repair of the fallopian tubes, or removal of scarring (adhesions) within the womb or abdominal cavity
- assisted conception such as intrauterine insemination (IUI) or IVF
The treatment offered will depend on what’s causing the fertility problems and what’s available from your local clinical commissioning group (CCG).
Private treatment is also available, but it can be expensive and there’s no guarantee it will be successful.
It’s important to choose a private clinic carefully. You can ask a GP for advice, and should make sure you choose a clinic that’s licensed by the Human Fertilisation and Embryology Authority (HFEA).
Some treatments for infertility, such as IVF, can cause complications.
- multiple pregnancy – if more than 1 embryo is placed in the womb as part of IVF treatment there’s an increased chance of having twins; this may not seem like a bad thing, but it significantly increases the risk of complications for you and your babies
- ectopic pregnancy – the risk of having an ectopic pregnancy is slightly increased if you have IVF
Read more about how infertility is treated.
There are many possible causes of infertility, and fertility problems can affect either partner. But in a quarter of cases it is not possible to identify the cause.
Common causes of infertility include:
- lack of regular ovulation (the monthly release of an egg)
- poor quality semen
- blocked or damaged fallopian tubes
- endometriosis – where tissue that behaves like the lining of the womb (the endometrium) is found outside the womb
There are also several factors that can affect fertility.
- age – fertility declines with age
- weight – being overweight or obese (having a BMI of 30 or over) reduces fertility; in women, being overweight or severely underweight can affect ovulation
- sexually transmitted infections (STIs) – several STIs, including chlamydia, can affect fertility
- smoking – can affect fertility: smoking (including passive smoking) affects your chance of conceiving and can reduce semen quality; read more about quitting smoking
- alcohol – the safest approach is not to drink alcohol at all to keep risks to your baby to a minimum. Drinking too much alcohol can also affect the quality of sperm (the chief medical officers for the UK recommend adults should drink no more than 14 units of alcohol a week, which should be spread evenly over 3 days or more)
- environmental factors – exposure to certain pesticides, solvents and metals has been shown to affect fertility, particularly in men
- stress – can affect your relationship with your partner and cause a loss of sex drive; in severe cases, stress may also affect ovulation and sperm production
There’s no evidence to suggest caffeinated drinks, such as tea, coffee and colas, are associated with fertility problems.